4B2D

human PKM2 with L-serine and FBP bound.

Summary for 4B2D

• Entry DOI: 10.2210/pdb4b2d/pdb
• Related: 1T5A
• Descriptor: PYRUVATE KINASE ISOZYMES M1/M2, SERINE, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (6 entities in total)
• Functional Keywords: transferase, tumour, pkm2, glycolysis
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 241156.73

Authors

Chaneton, B.,Hillmann, P.,Zheng, L.,Martin, A.C.L.,Maddocks, O.D.K.,Chokkathukalam, A.,Coyle, J.E.,Jankevics, A.,Holding, F.P.,Vousden, K.H.,Frezza, C.,O'Reilly, M.,Gottlieb, E. (deposition date: 2012-07-13, release date: 2012-10-10, Last modification date: 2023-12-20)

• Primary citation: Chaneton, B.,Hillmann, P.,Zheng, L.,Martin, A.C.L.,Maddocks, O.D.K.,Chokkathukalam, A.,Coyle, J.E.,Jankevics, A.,Holding, F.P.,Vousden, K.H.,Frezza, C.,O'Reilly, M.,Gottlieb, E.; Serine is a natural ligand and allosteric activator of pyruvate kinase M2.; Nature, 491:458-462, 2012; PubMed: 23064226; DOI: 10.1038/nature11540

Experimental method

X-RAY DIFFRACTION (2.3 Å)