4B18

The crystal structure of human Importin alpha 5 with TERT NLS peptide

Summary for 4B18

• Entry DOI: 10.2210/pdb4b18/pdb
• Related: 2BCK 2JDQ
• Descriptor: IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE TRANSCRIPTASE (3 entities in total)
• Functional Keywords: transport protein - peptide complex, transport protein / peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm : P52294; Nucleus, nucleolus: O14746
• Total number of polymer chains: 2
• Total formula weight: 51684.03

Authors

Kim, K.L.,Yoo, J.H.,Cho, H.S. (deposition date: 2012-07-08, release date: 2013-09-04, Last modification date: 2023-12-20)

• Primary citation: Jeong, S.A.,Kim, K.,Lee, J.H.,Cha, J.S.,Khadka, P.,Cho, H.,Chung, I.K.; Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation.; J.Cell.Sci., 128:2287-, 2015; PubMed: 25999477; DOI: 10.1242/JCS.166132

Experimental method

X-RAY DIFFRACTION (2.52 Å)