4AZ3

crystal structure of cathepsin a, complexed with 15a

Summary for 4AZ3

Entry DOI	10.2210/pdb4az3/pdb
Related	1IVY 4AZ0
Descriptor	LYSOSOMAL PROTECTIVE PROTEIN 32 KDA CHAIN, LYSOSOMAL PROTECTIVE PROTEIN 20 KDA CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase, drug discovery, carboxypeptidase, cardiovascular
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	53629.45
Authors	Ruf, S.,Buning, C.,Schreuder, H.,Horstick, G.,Linz, W.,Olpp, T.,Pernerstorfer, J.,Hiss, K.,Kroll, K.,Kannt, A.,Kohlmann, M.,Linz, D.,Huebschle, T.,Ruetten, H.,Wirth, K.,Schmidt, T.,Sadowski, T. (deposition date: 2012-06-22, release date: 2012-09-26, Last modification date: 2023-12-20)
Primary citation	Ruf, S.,Buning, C.,Schreuder, H.,Horstick, G.,Linz, W.,Olpp, T.,Pernerstorfer, J.,Hiss, K.,Kroll, K.,Kannt, A.,Kohlmann, M.,Linz, D.,Hubschle, T.,Rutten, H.,Wirth, K.,Schmidt, T.,Sadowski, T. Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A. J.Med.Chem., 55:7636-, 2012 Cited by PubMed: 22861813 DOI: 10.1021/JM300663N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation