4AY5

Human O-GlcNAc transferase (OGT) in complex with UDP and glycopeptide

Summary for 4AY5

• Entry DOI: 10.2210/pdb4ay5/pdb
• Related: 1W3B 4AY6
• Descriptor: UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYL TRANSFERASE 110 KDA SUBUNIT, GTAB1TIDE, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: transferase-peptide complex, transferase, glycosyl transferase, trimeric product complex, o-glcnac, transferase/peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 8
• Total formula weight: 330884.30

Authors

Schimpl, M.,Zheng, X.,Blair, D.E.,Schuettelkopf, A.W.,Navratilova, I.,Aristotelous, T.,Ferenbach, A.T.,Macnaughtan, M.A.,Borodkin, V.S.,van Aalten, D.M.F. (deposition date: 2012-06-18, release date: 2012-10-24, Last modification date: 2020-07-29)

• Primary citation: Schimpl, M.,Zheng, X.,Borodkin, V.S.,Blair, D.E.,Ferenbach, A.T.,Schuettelkopf, A.W.,Navratilova, I.,Aristotelous, T.,Albarbarawi, O.,Robinson, D.A.,Macnaughtan, M.A.,Van Aalten, D.M.F.; O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis; Nat.Chem.Biol., 8:969-, 2012; PubMed: 23103942; DOI: 10.1038/NCHEMBIO.1108

Experimental method

X-RAY DIFFRACTION (3.15 Å)