4AS0

Cyclometalated Phthalimides as Protein Kinase Inhibitors

Summary for 4AS0

Entry DOI	10.2210/pdb4as0/pdb
Related	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 4A7C 4ALU 4ALV 4ALW
Descriptor	SERINE/THREONINE-PROTEIN KINASE PIM-1, PHTALIMIDE-RUTHENIUM COMPLEX (3 entities in total)
Functional Keywords	transferase, pim1, octasporine, ruthenium, kinase inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	31950.29
Authors	Blanck, S.,Geisselbrecht, Y.,Middel, S.,Mietke, T.,Harms, K.,Essen, L.-O.,Meggers, E. (deposition date: 2012-04-27, release date: 2012-10-03, Last modification date: 2023-12-20)
Primary citation	Blanck, S.,Geisselbrecht, Y.,Kraling, K.,Middel, S.,Mietke, T.,Harms, K.,Essen, L.-O.,Meggers, E. Bioactive Cyclometalated Phthalimides: Design, Synthesis and Kinase Inhibition. Dalton Trans, 41:9337-, 2012 Cited by PubMed: 22733119 DOI: 10.1039/C2DT30940H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation