4AQC

Triazolopyridine-based Inhibitor of Janus Kinase 2

Summary for 4AQC

Entry DOI	10.2210/pdb4aqc/pdb
Related	2B7A 2W1I 2XA4
Descriptor	TYROSINE-PROTEIN KINASE JAK2, 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, atp-binding
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	72294.01
Authors	Dugan, B.J.,Gingrich, D.E.,Mesaros, E.F.,Milkiewicz, K.L.,Curry, M.A.,Zulli, A.L.,Dobrzanski, P.,Serdikoff, C.,Jan, M.,Angeles, T.S.,Albom, M.S.,Mason, J.L.,Aimone, L.D.,Meyer, S.L.,Huang, Z.,Wells-Knecht, K.J.,Ator, M.A.,Ruggeri, B.A.,Dorsey, B.D. (deposition date: 2012-04-16, release date: 2012-04-25, Last modification date: 2019-05-08)
Primary citation	Dugan, B.J.,Gingrich, D.E.,Mesaros, E.F.,Milkiewicz, K.L.,Curry, M.A.,Zulli, A.L.,Dobrzanski, P.,Serdikoff, C.,Jan, M.,Angeles, T.S.,Albom, M.S.,Mason, J.L.,Aimone, L.D.,Meyer, S.L.,Huang, Z.,Wells-Knecht, K.J.,Ator, M.A.,Ruggeri, B.A.,Dorsey, B.D. A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779. J.Med.Chem., 55:5243-, 2012 Cited by PubMed: 22594690 DOI: 10.1021/JM300248Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation