4ALU

Benzofuropyrimidinone Inhibitors of Pim-1

Summary for 4ALU

• Entry DOI: 10.2210/pdb4alu/pdb
• Related: 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 4A7C 4ALV 4ALW
• Descriptor: SERINE/THREONINE-PROTEIN KINASE PIM-1, IMIDAZOLE, 8-bromo-2-(2-chlorophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, ... (4 entities in total)
• Functional Keywords: proto-oncogene, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 37942.25

Authors

Stout, T.J.,Adams, L. (deposition date: 2012-03-05, release date: 2013-01-16, Last modification date: 2017-06-28)

• Primary citation: Tsuhako, A.L.,Brown, D.S.,Koltun, E.S.,Aay, N.,Arcalas, A.,Chan, V.,Du, H.,Engst, S.,Franzini, M.,Galan, A.,Huang, P.,Johnston, S.,Kane, B.,Kim, M.H.,Laird, A.D.,Lin, R.,Mock, L.,Ngan, I.,Pack, M.,Stott, G.,Stout, T.J.,Yu, P.,Zaharia, C.,Zhang, W.,Zhou, P.,Nuss, J.M.,Kearney, P.C.,Xu, W.; The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors.; Bioorg.Med.Chem.Lett., 22:3732-, 2012; PubMed: 22542012; DOI: 10.1016/J.BMCL.2012.04.025

Experimental method

X-RAY DIFFRACTION (2.6 Å)