4AH7

Structure of Wild Type Stapylococcus aureus N-acetylneuraminic acid lyase in complex with pyruvate

Summary for 4AH7

• Entry DOI: 10.2210/pdb4ah7/pdb
• Related: 4AH8 4AHO 4AHP 4AHQ
• Descriptor: N-ACETYLNEURAMINATE LYASE (2 entities in total)
• Functional Keywords: lyase
• Biological source: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS NCTC 8325
• Cellular location: Cytoplasm (By similarity): Q2G160
• Total number of polymer chains: 4
• Total formula weight: 135372.74

Authors

Timms, N.,Poyakova, A.,Windle, C.L.,Trinh, C.H.,Nelson, A.,Pearson, A.R.,Berry, A. (deposition date: 2012-02-03, release date: 2013-01-23, Last modification date: 2013-03-13)

• Primary citation: Timms, N.,Windle, C.L.,Polyakova, A.,Ault, J.R.,Trinh, C.H.,Pearson, A.R.,Nelson, A.,Berry, A.; Structural Insights Into the Recovery of Aldolase Activity in N-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with Gamma-Thialysine by Using a Chemical Mutagenesis Strategy.; Chembiochem, 14:474-, 2013; PubMed: 23418011; DOI: 10.1002/CBIC.201200714

Experimental method

X-RAY DIFFRACTION (2.3 Å)