4A55

Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108

Summary for 4A55

Entry DOI	10.2210/pdb4a55/pdb
Related	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2V1Y
Descriptor	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PIK-108 (3 entities in total)
Functional Keywords	transferase, oncogene, lipid kinase, membrane binding, cancer mutations, tumours, growth factor signalling, pi3-kinase inhibitor, non-atp competitive ligand binding site, structure-activity relationship, enzyme regulation
Biological source	MUS MUSCULUS (HOUSE MOUSE) More
Total number of polymer chains	2
Total formula weight	162413.45
Authors	Hon, W.-C.,Berndt, A.,Williams, R.L. (deposition date: 2011-10-24, release date: 2011-12-28, Last modification date: 2023-12-20)
Primary citation	Hon, W.-C.,Berndt, A.,Williams, R.L. Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases. Oncogene, 31:3655-, 2012 Cited by PubMed: 22120714 DOI: 10.1038/ONC.2011.532 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation