3ZYA
Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone
Summary for 3ZYA
| Entry DOI | 10.2210/pdb3zya/pdb |
| Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIS 2YIW 2YIX 3ZS5 3ZSG 3ZSH 3ZSI |
| Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, 2-AMINO-PHENYLAMINO-DIBENZOSUBERONE (3 entities in total) |
| Functional Keywords | transferase, allosteric regulation, protein kinase inhibitor, structure-activity relationship, p38 mitogen-activated protein kinases |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm (By similarity): Q16539 |
| Total number of polymer chains | 1 |
| Total formula weight | 42313.32 |
| Authors | Romir, J.,Koeberle, S.C.,Laufer, S.A.,Stehle, T. (deposition date: 2011-08-18, release date: 2011-12-28, Last modification date: 2023-12-20) |
| Primary citation | Koeberle, S.C.,Romir, J.,Fischer, S.,Koeberle, A.,Schattel, V.,Albrecht, W.,Grutter, C.,Werz, O.,Rauh, D.,Stehle, T.,Laufer, S.A. Skepinone-L is a Selective P38 Mitogen-Activated Protein Kinase Inhibitor. Nat.Chem.Biol., 8:141-, 2011 Cited by PubMed: 22198732DOI: 10.1038/NCHEMBIO.761 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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