3ZS1
Human Myeloperoxidase inactivated by TX5
Summary for 3ZS1
Entry DOI | 10.2210/pdb3zs1/pdb |
Related | 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3ZS0 |
Descriptor | MYELOPEROXIDASE LIGHT CHAIN, ACETATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total) |
Functional Keywords | oxidoreductase, enzyme inactivation, inflammation, neutrophil, reactive oxygen species (ros), hypochlorous acid |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Lysosome: P05164 P05164 |
Total number of polymer chains | 4 |
Total formula weight | 137114.53 |
Authors | Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Jameson, G.N.,Eriksson, H.,Kettle, A.J. (deposition date: 2011-06-21, release date: 2011-08-31, Last modification date: 2023-12-20) |
Primary citation | Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Paton, L.N.,Jameson, G.N.,Eriksson, H.,Kettle, A.J. 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation. J.Biol.Chem., 286:37578-, 2011 Cited by PubMed: 21880720DOI: 10.1074/JBC.M111.266981 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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