3ZS1

Human Myeloperoxidase inactivated by TX5

Summary for 3ZS1

• Entry DOI: 10.2210/pdb3zs1/pdb
• Related: 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3ZS0
• Descriptor: MYELOPEROXIDASE LIGHT CHAIN, ACETATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: oxidoreductase, enzyme inactivation, inflammation, neutrophil, reactive oxygen species (ros), hypochlorous acid
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Lysosome: P05164 P05164
• Total number of polymer chains: 4
• Total formula weight: 137114.53

Authors

Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Jameson, G.N.,Eriksson, H.,Kettle, A.J. (deposition date: 2011-06-21, release date: 2011-08-31, Last modification date: 2023-12-20)

• Primary citation: Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Paton, L.N.,Jameson, G.N.,Eriksson, H.,Kettle, A.J.; 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.; J.Biol.Chem., 286:37578-, 2011; PubMed: 21880720; DOI: 10.1074/JBC.M111.266981

Experimental method

X-RAY DIFFRACTION (2.6 Å)