3ZMM

Inhibitors of Jak2 Kinase domain

Summary for 3ZMM

Entry DOI	10.2210/pdb3zmm/pdb
Descriptor	TYROSINE-PROTEIN KINASE JAK2, 5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY]-N-(5-METHYL-1H-PYRAZOL-3-YL)-6-MORPHOLINO-PYRIMIDIN-2-AMINE, ACETYL GROUP, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains	2
Total formula weight	71160.59
Authors	Read, J.,Green, I.,Pollard, H.,Howard, T.,Mott, R. (deposition date: 2013-02-11, release date: 2013-04-17, Last modification date: 2023-12-20)
Primary citation	Guan, H.,Lamb, M.L.,Peng, B.,Huang, S.,Degrace, N.,Read, J.,Hussain, S.,Wu, J.,Rivard, C.,Alimzhanov, M.,Bebernitz, G.,Bell, K.,Ye, M.,Zinda, M.,Ioannidis, S. Discovery of Novel Jak2-Stat Pathway Inhibitors with Extended Residence Time on Target. Bioorg.Med.Chem.Lett., 23:3105-, 2013 Cited by PubMed: 23562594 DOI: 10.1016/J.BMCL.2013.02.111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation