3ZKI

BACE2 MUTANT STRUCTURE WITH LIGAND

Summary for 3ZKI

• Entry DOI: 10.2210/pdb3zki/pdb
• Related: 3ZKG 3ZKM 3ZKN 3ZKQ 3ZKX 3ZL7 3ZOV
• Descriptor: BETA-SECRETASE 2, 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide (3 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Membrane; Single-pass type I membrane protein: Q9Y5Z0
• Total number of polymer chains: 2
• Total formula weight: 84965.51

Authors

Banner, D.W.,Kuglstatter, A.,Benz, J.,Stihle, M.,Ruf, A. (deposition date: 2013-01-23, release date: 2013-05-29, Last modification date: 2023-12-20)

• Primary citation: Banner, D.W.,Gsell, B.,Benz, J.,Bertschinger, J.,Burger, D.,Brack, S.,Cuppuleri, S.,Debulpaep, M.,Gast, A.,Grabulovski, D.,Hennig, M.,Hilpert, H.,Huber, W.,Kuglstatter, A.,Kusznir, E.,Laeremans, T.,Matile, H.,Miscenic, C.,Rufer, A.,Schlatter, D.,Steyeart, J.,Stihle, M.,Thoma, R.,Weber, M.,Ruf, A.; Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones; Acta Crystallogr.,Sect.D, 69:1124-, 2013; PubMed: 23695257; DOI: 10.1107/S0907444913006574

Experimental method

X-RAY DIFFRACTION (2.4 Å)