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3ZIM

Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha

Summary for 3ZIM
Entry DOI10.2210/pdb3zim/pdb
DescriptorPHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4-dione (3 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight109980.19
Authors
Primary citationNacht, M.,Qiao, L.,Sheets, M.P.,Martin, T.S.,Labenski, M.,Mazdiyasni, H.,Karp, R.,Zhu, Z.,Chaturvedi, P.,Bhavsar, D.,Niu, D.,Westlin, W.,Petter, R.C.,Medikonda, A.P.,Singh, J.
Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha
J.Med.Chem., 56:712-, 2013
Cited by
PubMed: 23360348
DOI: 10.1021/JM3008745
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

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