3ZGP

NMR structure of the catalytic domain from E. faecium L,D- transpeptidase acylated by ertapenem

Summary for 3ZGP

• Entry DOI: 10.2210/pdb3zgp/pdb
• Related: 3ZG4
• NMR Information: BMRB: 18911
• Descriptor: ERFK/YBIS/YCFS/YNHG, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid (2 entities in total)
• Functional Keywords: transferase, transpeptidation, peptidoglycan biosynthesis, antibiotic resistance
• Biological source: ENTEROCOCCUS FAECIUM
• Total number of polymer chains: 1
• Total formula weight: 15049.68

Authors

Lecoq, L.,Triboulet, S.,Dubee, V.,Bougault, C.,Hugonnet, J.E.,Arthur, M.,Simorre, J.P. (deposition date: 2012-12-18, release date: 2013-04-24, Last modification date: 2023-06-14)

• Primary citation: Lecoq, L.,Triboulet, S.,Dubee, V.,Bougault, C.,Hugonnet, J.E.,Arthur, M.,Simorre, J.P.; The Structure of Enterococcus Faecium L,D---Transpeptidase Acylated by Ertapenem Provides Insight Into the Inactivation Mechanism.; Acs Chem.Biol., 8:1140-1146, 2013; PubMed: 23574509; DOI: 10.1021/cb4001603

Experimental method

SOLUTION NMR