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3ZGN

Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway

Summary for 3ZGN
Entry DOI10.2210/pdb3zgn/pdb
Related3ZGL
Descriptor4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, (2E)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate, IRON/SULFUR CLUSTER, ... (4 entities in total)
Functional Keywordsoxidoreductase, mep pathway, inhibitors, 4fe-4s cluster
Biological sourceESCHERICHIA COLI
Total number of polymer chains2
Total formula weight74538.63
Authors
Borel, F.,Barbier, E.,Kratsutsky, S.,Janthawornpong, K.,Rohmer, M.,Dale Poulter, C.,Ferrer, J.L.,Seemann, M. (deposition date: 2012-12-18, release date: 2013-01-09, Last modification date: 2023-12-20)
Primary citationBorel, F.,Barbier, E.,Krasutsky, S.,Janthawornpong, K.,Chaignon, P.,Poulter, C.D.,Ferrer, J.L.,Seemann, M.
Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.
Chembiochem, 18:2137-2144, 2017
Cited by
PubMed: 28862365
DOI: 10.1002/cbic.201700363
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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