3WU0

Crystal structure of phosphorylated ETS-1 DNA binding and autoinhibitory domains (276-441)

Summary for 3WU0

Entry DOI	10.2210/pdb3wu0/pdb
Related	3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU1
Descriptor	Protein C-ets-1 (2 entities in total)
Functional Keywords	phosphorylation, transcription, ets-1, autoinhibition, ets domain, dna-binding, isopeptide bond, nucleus, phosphoprotein, proto-oncogene, transcription regulation
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P14921
Total number of polymer chains	2
Total formula weight	38433.46
Authors	Shiina, M.,Hamada, K.,Ogata, K. (deposition date: 2014-04-21, release date: 2014-08-20, Last modification date: 2023-11-08)
Primary citation	Shiina, M.,Hamada, K.,Inoue-Bungo, T.,Shimamura, M.,Uchiyama, A.,Baba, S.,Sato, K.,Yamamoto, M.,Ogata, K. A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427:1655-1669, 2015 Cited by PubMed: 25083921 DOI: 10.1016/j.jmb.2014.07.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation