3WTW

Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA

Summary for 3WTW

• Entry DOI: 10.2210/pdb3wtw/pdb
• Related: 3WTS 3WTT 3WTU 3WTV 3WTX 3WTY 3WTZ 3WU0 3WU1
• Descriptor: Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ... (6 entities in total)
• Functional Keywords: protein-dna complex, transcription, dna-binding, methylation, nucleus, phosphoprotein, transcription regulation, isopeptide bond, proto-oncogene, transcription-dna complex, transcription/dna
• Biological source: Mus musculus (mouse); More
• Cellular location: Nucleus : Q03347 Q08024; Cytoplasm : P14921
• Total number of polymer chains: 10
• Total formula weight: 135872.26

Authors

Shiina, M.,Hamada, K.,Ogata, K. (deposition date: 2014-04-21, release date: 2014-08-20, Last modification date: 2023-11-08)

• Primary citation: Shiina, M.,Hamada, K.,Inoue-Bungo, T.,Shimamura, M.,Uchiyama, A.,Baba, S.,Sato, K.,Yamamoto, M.,Ogata, K.; A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.; J.Mol.Biol., 427:1655-1669, 2015; PubMed: 25083921; DOI: 10.1016/j.jmb.2014.07.020

Experimental method

X-RAY DIFFRACTION (2.9 Å)