3WQ9

Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide

Summary for 3WQ9

• Entry DOI: 10.2210/pdb3wq9/pdb
• Descriptor: Heat shock protein HSP 90-alpha, 2-[(trans-4-hydroxycyclohexyl)amino]-4-[5-(4-phenyl-1H-imidazol-1-yl)isoquinolin-1-yl]benzamide (3 entities in total)
• Functional Keywords: hydrolase, atp binding, chaperone
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 27243.52

Authors

Chong, K.T.,Yamashita, S.,Oshiumi, H.,Uno, T.,Kitade, M. (deposition date: 2014-01-23, release date: 2015-02-25, Last modification date: 2024-03-20)

• Primary citation: Yoshimura, C.,Yamashita, S.,Oshiumi, H.,Uno, T.,Kawai, Y.,Chong, K.T.,Kodama, Y.,Kitade, M.,Ohkubo, S.; Evolution of highly selective Hsp90 / inhibitors by structure and thermodynamics guided design; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)