3WBL
Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor
Summary for 3WBL
Entry DOI | 10.2210/pdb3wbl/pdb |
Related | 3A2C |
Descriptor | Cyclin-dependent kinase 2, ACETATE ION, N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine, ... (4 entities in total) |
Functional Keywords | binding sites, tumor, cyclin-dependent kinase 2, drug design, map kinase kinase 2, mk2, protein kinase inhibitors, pyrazoles, pyrimidines, structure-activity relationship, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34401.99 |
Authors | Fujino, A.,Fukushima, K.,Kubota, T.,Kosugi, T.,Takimoto-Kamimura, M. (deposition date: 2013-05-20, release date: 2013-10-30, Last modification date: 2023-11-08) |
Primary citation | Fujino, A.,Fukushima, K.,Kubota, T.,Kosugi, T.,Takimoto-Kamimura, M. Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity. J.SYNCHROTRON RADIAT., 20:905-909, 2013 Cited by PubMed: 24121337DOI: 10.1107/S0909049513020736 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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