3WAV

Crystal Structure of Autotaxin in Complex with Compound 10

Summary for 3WAV

Entry DOI	10.2210/pdb3wav/pdb
Related	3WAW 3WAX 3WAY
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, SULFATE ION, (5Z)-5-(3,4-dichlorobenzylidene)-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4(5H)-one, ... (12 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	99597.90
Authors	Nishimasu, H.,Ishitani, R.,Nureki, O. (deposition date: 2013-05-09, release date: 2013-07-31, Last modification date: 2023-11-08)
Primary citation	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T. Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8:1713-1721, 2013 Cited by PubMed: 23688339 DOI: 10.1021/cb400150c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.797 Å)

Structure validation