3W87

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-103

Summary for 3W87

• Entry DOI: 10.2210/pdb3w87/pdb
• Related: 3W1A 3W1L 3W1M 3W1N 3W1P 3W1Q 3W1R 3W1T 3W1U 3W1X 3W22 3W23 3W2J 3W2K 3W2L 3W2M 3W2N 3W2U 3W6Y 3W70 3W71 3W72 3W73 3W74 3W75 3W76 3W7C 3W7D 3W7E 3W7G 3W7H 3W7I 3W7J 3W7K 3W7L 3W7M 3W7N 3W7O 3W7P 3W7Q 3W83 3W84 3W85 3W86 4JD4 4JDB
• Descriptor: Dihydroorotate dehydrogenase (fumarate), 5-{4-[5-(methoxycarbonyl)naphthalen-2-yl]butyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, GLYCEROL, ... (9 entities in total)
• Functional Keywords: rossmann fold, oxidoreductase, dihydroorotate/orotate and fumarate/succinate binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Trypanosoma cruzi
• Cellular location: Cytoplasm : Q4D3W2
• Total number of polymer chains: 2
• Total formula weight: 74994.64

Authors

Inaoka, D.K.,Hashimoto, S.,Rocha, J.R.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Balogun, E.O.,Sakamoto, K.,Suzuki, S.,Montanari, C.A.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. (deposition date: 2013-03-12, release date: 2014-04-09, Last modification date: 2023-11-08)

• Primary citation: Inaoka, D.K.,Hashimoto, S.,Rocha, J.R.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Balogun, E.O.,Sakamoto, K.,Suzuki, S.,Montanari, C.A.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K.; Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-103; To be Published,

Experimental method

X-RAY DIFFRACTION (1.43 Å)