3W69

Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor

Summary for 3W69

Entry DOI	10.2210/pdb3w69/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole, SULFATE ION, ... (4 entities in total)
Functional Keywords	ubiquitin-protein ligase e3 mdm2, p53, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	2
Total formula weight	22091.59
Authors	Shimizu, H.,Katakura, S.,Miyazaki, M.,Naito, H.,Sugimoto, Y.,Kawato, H.,Okayama, T.,Soga, T. (deposition date: 2013-02-12, release date: 2013-06-05, Last modification date: 2023-11-08)
Primary citation	Miyazaki, M.,Naito, H.,Sugimoto, Y.,Yoshida, K.,Kawato, H.,Okayama, T.,Shimizu, H.,Miyazaki, M.,Kitagawa, M.,Seki, T.,Fukutake, S.,Shiose, Y.,Aonuma, M.,Soga, T. Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors Bioorg.Med.Chem., 21:4319-4331, 2013 Cited by PubMed: 23685175 DOI: 10.1016/j.bmc.2013.04.056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation