3W3N

Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3

Summary for 3W3N

Entry DOI	10.2210/pdb3w3n/pdb
Related	3W3G 3W3J 3W3K 3W3L 3W3M
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	leucine rich repeat, rna, glycosylation, rna recognition, ssrna, receptor, rna receptor, innate immunity, rna binding, secreted, resiquimod, antivirus and antitumor drug, antivirus and antitumor drug binding, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	194083.67
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2012-12-22, release date: 2013-04-03, Last modification date: 2023-11-29)
Primary citation	Tanji, H.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands Science, 339:1426-1429, 2013 Cited by PubMed: 23520111 DOI: 10.1126/science.1229159 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation