3W32

EGFR kinase domain complexed with compound 20a

Summary for 3W32

Entry DOI	10.2210/pdb3w32/pdb
Related	3POZ 3W33
Descriptor	Epidermal growth factor receptor, 4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-N-[2-(methylsulfonyl)ethyl]-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	anti-oncogene, cell cycle, disease mutation, kinase domain, receptor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38241.51
Authors	Sogabe, S.,Kawakita, Y. (deposition date: 2012-12-07, release date: 2013-03-06, Last modification date: 2023-11-08)
Primary citation	Kawakita, Y.,Seto, M.,Ohashi, T.,Tamura, T.,Yusa, T.,Miki, H.,Iwata, H.,Kamiguchi, H.,Tanaka, T.,Sogabe, S.,Ohta, Y.,Ishikawa, T. Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors Bioorg.Med.Chem., 21:2250-2261, 2013 Cited by PubMed: 23490150 DOI: 10.1016/j.bmc.2013.02.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation