3W0I

Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands

Summary for 3W0I

• Entry DOI: 10.2210/pdb3w0i/pdb
• Related: 3W0G 3W0H 3W0J
• Descriptor: Vitamin D3 Receptor, Mediator of RNA polymerase II transcription subunit 1, (2S)-3-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}phenyl)pentan-3-yl]phenoxy}propane-1,2-diol, ... (4 entities in total)
• Functional Keywords: gene regulation, transcription
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Nucleus: P13053 Q15648
• Total number of polymer chains: 2
• Total formula weight: 30756.50

Authors

Shimizu, T.,Asano, L.,Kuwabara, N.,Ito, I.,Waku, T.,Yanagisawa, J.,Miyachi, H. (deposition date: 2012-10-30, release date: 2013-10-09, Last modification date: 2023-11-08)

• Primary citation: Asano, L.,Ito, I.,Kuwabara, N.,Waku, T.,Yanagisawa, J.,Miyachi, H.,Shimizu, T.; Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands.; Febs Lett., 587:957-963, 2013; PubMed: 23462137; DOI: 10.1016/j.febslet.2013.02.028

Experimental method

X-RAY DIFFRACTION (1.9 Å)