3W09

Influenza virus neuraminidase subtype N9 (TERN) complexed with 2,3-dif guanidino-neu5ac2en inhibitor

Summary for 3W09

• Entry DOI: 10.2210/pdb3w09/pdb
• Related: 1NNC 7NN9
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: neuraminidase, sialidase, hydrolase(o-glucosyl), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Cellular location: Virion membrane (By similarity): P03472
• Total number of polymer chains: 1
• Total formula weight: 46963.80

Authors

Streltsov, V.A. (deposition date: 2012-10-25, release date: 2013-05-01, Last modification date: 2023-11-08)

• Primary citation: Kim, J.-H.,Resende, R.,Wennekes, T.,Chen, H.M.,Bance, N.,Buchini, S.,Watts, A.G.,Pilling, P.,Streltsov, V.A.,Petric, M.,Liggins, R.,Barrett, S.,McKimm-Breschkin, J.L.,Niikura, M.,Withers, S.G.; Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity; Science, 340:71-75, 2013; PubMed: 23429702; DOI: 10.1126/science.1232552

Experimental method

X-RAY DIFFRACTION (2 Å)