3VYD

Human renin in complex with inhibitor 6

Summary for 3VYD

Entry DOI	10.2210/pdb3vyd/pdb
Related	3VYE 3VYF
Descriptor	Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,5R)-5-{[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]methyl}-N-(3-methylbutyl)piperidine-3-carboxamide, ... (4 entities in total)
Functional Keywords	aspartyl protease, ras, hypertension, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	75874.49
Authors	Takahashi, M.,Hanzawa, H. (deposition date: 2012-09-24, release date: 2012-12-19, Last modification date: 2023-11-08)
Primary citation	Mori, Y.,Ogawa, Y.,Mochizuki, A.,Nakamura, Y.,Sugita, C.,Miyazaki, S.,Tamaki, K.,Matsui, Y.,Takahashi, M.,Nagayama, T.,Nagai, Y.,Inoue, S.,Nishi, T. Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors Bioorg.Med.Chem.Lett., 22:7677-7682, 2012 Cited by PubMed: 23122821 DOI: 10.1016/j.bmcl.2012.09.103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation