3VXF

X/N Joint refinement of Human alpha-thrombin-Bivalirudin complex PD5

Summary for 3VXF

• Entry DOI: 10.2210/pdb3vxf/pdb
• Related: 3VXE
• Related PRD ID: PRD_001145 PRD_001148
• Descriptor: Thrombin light chain, Thrombin heavy chain, BIVALIRUDIN, ... (6 entities in total)
• Functional Keywords: serine protease, hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 36297.27

Authors

Yamada, T.,Kurihara, K.,Masumi, K.,Tamada, T.,Tomoyori, K.,Ohnishi, Y.,Tanaka, I.,Kuroki, R.,Niimura, N. (deposition date: 2012-09-12, release date: 2013-09-04, Last modification date: 2020-07-29)

• Primary citation: Yamada, T.,Kurihara, K.,Ohnishi, Y.,Tamada, T.,Tomoyori, K.,Masumi, K.,Tanaka, I.,Kuroki, R.,Niimura, N.; Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex; Biochim.Biophys.Acta, 1834:1532-1538, 2013; PubMed: 23712263; DOI: 10.1016/j.bbapap.2013.05.014

Experimental method

NEUTRON DIFFRACTION (2.752 Å)
X-RAY DIFFRACTION (1.602 Å)