3VUZ

Crystal structure of histone methyltransferase SET7/9 in complex with AAM-1

Summary for 3VUZ

• Entry DOI: 10.2210/pdb3vuz/pdb
• Related: 3VV0
• Descriptor: Histone-lysine N-methyltransferase SETD7, 5'-{[(3S)-3-amino-3-carboxypropyl](hexyl)amino}-5'-deoxyadenosine (3 entities in total)
• Functional Keywords: set domain, transferase, adenosylmethionine binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q8WTS6
• Total number of polymer chains: 1
• Total formula weight: 29534.76

Authors

Niwa, H.,Handa, N.,Tomabechi, Y.,Honda, K.,Toyama, M.,Ohsawa, N.,Shirouzu, M.,Kagechika, H.,Hirano, T.,Umehara, T.,Yokoyama, S. (deposition date: 2012-07-10, release date: 2013-03-27, Last modification date: 2023-11-08)

• Primary citation: Niwa, H.,Handa, N.,Tomabechi, Y.,Honda, K.,Toyama, M.,Ohsawa, N.,Shirouzu, M.,Kagechika, H.,Hirano, T.,Umehara, T.,Yokoyama, S.; Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives; Acta Crystallogr.,Sect.D, 69:595-602, 2013; PubMed: 23519668; DOI: 10.1107/S0907444912052092

Experimental method

X-RAY DIFFRACTION (2.5 Å)