3VRW

VDR ligand binding domain in complex with 22S-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3

Summary for 3VRW

Entry DOI	10.2210/pdb3vrw/pdb
Related	3VRT 3VRU 3VRV
Descriptor	Vitamin D3 receptor, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-[(2R,3S)-3-butyl-5-ethyl-5-hydroxyheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, transcription, vitamin d3, vdre, rxr, co-factors, nuclear
Biological source	Rattus norvegicus (Rat) More
Cellular location	Nucleus: P13053 Q15648
Total number of polymer chains	2
Total formula weight	32652.70
Authors	Yoshimoto, N.,Inaba, Y.,Itoh, T.,Nakabayashi, M.,Ito, N.,Yamamoto, K. (deposition date: 2012-04-16, release date: 2012-05-23, Last modification date: 2024-03-20)
Primary citation	Yoshimoto, N.,Sakamaki, Y.,Haeta, M.,Kato, A.,Inaba, Y.,Itoh, T.,Nakabayashi, M.,Ito, N.,Yamamoto, K. Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands J.Med.Chem., 55:4373-4381, 2012 Cited by PubMed: 22512505 DOI: 10.1021/jm300230a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation