3VP1
Crystal structure of human glutaminase in complex with L-glutamate and BPTES
Summary for 3VP1
Entry DOI | 10.2210/pdb3vp1/pdb |
Descriptor | Glutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide), GLUTAMIC ACID, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925 |
Total number of polymer chains | 1 |
Total formula weight | 35552.55 |
Authors | Thangavelu, K.,Sivaraman, J. (deposition date: 2012-02-23, release date: 2012-06-13, Last modification date: 2023-11-08) |
Primary citation | Thangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J. Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012 Cited by PubMed: 22538822DOI: 10.1073/pnas.1116573109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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