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3VP1

Crystal structure of human glutaminase in complex with L-glutamate and BPTES

Summary for 3VP1
Entry DOI10.2210/pdb3vp1/pdb
DescriptorGlutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide), GLUTAMIC ACID, ... (5 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925
Total number of polymer chains1
Total formula weight35552.55
Authors
Thangavelu, K.,Sivaraman, J. (deposition date: 2012-02-23, release date: 2012-06-13, Last modification date: 2023-11-08)
Primary citationThangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J.
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012
Cited by
PubMed: 22538822
DOI: 10.1073/pnas.1116573109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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