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3VJK

Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with MP-513

3VJK の概要
エントリーDOI10.2210/pdb3vjk/pdb
関連するPDBエントリー3VJL 3VJM
分子名称Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone, ... (5 entities in total)
機能のキーワードalpha/beta, beta-propeller, aminopeptidase, serine protease, signal-anchor, transmembrane, diabetes, glycoprotein, cell membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Homo sapiens (human)
タンパク質・核酸の鎖数2
化学式量合計176283.68
構造登録者
Akahoshi, F.,Kishida, H.,Miyaguchi, I.,Yoshida, T.,Ishii, S. (登録日: 2011-10-24, 公開日: 2012-10-24, 最終更新日: 2023-11-08)
主引用文献Yoshida, T.,Akahoshi, F.,Sakashita, H.,Kitajima, H.,Nakamura, M.,Sonda, S.,Takeuchi, M.,Tanaka, Y.,Ueda, N.,Sekiguchi, S.,Ishige, T.,Shima, K.,Nabeno, M.,Abe, Y.,Anabuki, J.,Soejima, A.,Yoshida, K.,Takashina, Y.,Ishii, S.,Kiuchi, S.,Fukuda, S.,Tsutsumiuchi, R.,Kosaka, K.,Murozono, T.,Nakamaru, Y.,Utsumi, H.,Masutomi, N.,Kishida, H.,Miyaguchi, I.,Hayashi, Y.
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem., 20:5705-5719, 2012
Cited by
PubMed: 22959556
DOI: 10.1016/j.bmc.2012.08.012
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.49 Å)
構造検証レポート
Validation report summary of 3vjk
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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