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3VID

Crystal structure of human VEGFR2 kinase domain with Compound A.

Summary for 3VID
Entry DOI10.2210/pdb3vid/pdb
DescriptorVascular endothelial growth factor receptor 2, 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole (3 entities in total)
Functional Keywordskinase, transferase, phosphorylation
Biological sourceHomo sapiens (human)
Cellular locationCell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains1
Total formula weight40730.76
Authors
Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Hixon, M.S.,Kimura, H.,Miki, H. (deposition date: 2011-09-29, release date: 2012-08-15, Last modification date: 2024-03-20)
Primary citationIwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Lawson, J.D.,Hixon, M.S.,Kimura, H.,Miki, H.
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
ACS MED.CHEM.LETT., 3:342-346, 2012
Cited by
PubMed: 24900475
DOI: 10.1021/ml3000403
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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