3VHV

Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist

Summary for 3VHV

Entry DOI	10.2210/pdb3vhv/pdb
Related	3VHU
Descriptor	Mineralocorticoid receptor, 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one, 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one, ... (6 entities in total)
Functional Keywords	nuclear receptor, transcription factor, activating mutation, hypertension, non-steroidal antagonist, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P08235
Total number of polymer chains	1
Total formula weight	31051.99
Authors	Sogabe, S.,Habuka, N. (deposition date: 2011-09-07, release date: 2011-12-28, Last modification date: 2023-11-08)
Primary citation	Hasui, T.,Matsunaga, N.,Ora, T.,Ohyabu, N.,Nishigaki, N.,Imura, Y.,Igata, Y.,Matsui, H.,Motoyaji, T.,Tanaka, T.,Habuka, N.,Sogabe, S.,Ono, M.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists J.Med.Chem., 54:8616-8631, 2011 Cited by PubMed: 22074142 DOI: 10.1021/jm2011645 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation