3VHU

Mineralocorticoid receptor ligand-binding domain with spironolactone

Summary for 3VHU

Entry DOI	10.2210/pdb3vhu/pdb
Related	2AB2 2OAX 3VHV
Descriptor	Mineralocorticoid receptor, SPIRONOLACTONE (3 entities in total)
Functional Keywords	nuclear receptor, transcription factor, activating mutation, hypertension, antagonist, spironolactone, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P08235
Total number of polymer chains	1
Total formula weight	34422.79
Authors	Sogabe, S.,Habuka, N. (deposition date: 2011-09-07, release date: 2011-12-28, Last modification date: 2023-11-08)
Primary citation	Hasui, T.,Matsunaga, N.,Ora, T.,Ohyabu, N.,Nishigaki, N.,Imura, Y.,Igata, Y.,Matsui, H.,Motoyaji, T.,Tanaka, T.,Habuka, N.,Sogabe, S.,Ono, M.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists J.Med.Chem., 54:8616-8631, 2011 Cited by PubMed: 22074142 DOI: 10.1021/jm2011645 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation