3V5W

Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine

Summary for 3V5W

• Entry DOI: 10.2210/pdb3v5w/pdb
• Related: 3CIK 3KRW 3PVU 3PVW
• Descriptor: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: inhibitor complex, protein kinase, beta propeller, rgs homology domain, pleckstrin homology domain, kinase, signal transduction, peripheral membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
• Total number of polymer chains: 3
• Total formula weight: 126137.20

Authors

Thal, D.M.,Tesmer, J.J.G. (deposition date: 2011-12-17, release date: 2012-09-26, Last modification date: 2023-09-13)

• Primary citation: Thal, D.M.,Homan, K.T.,Chen, J.,Wu, E.K.,Hinkle, P.M.,Huang, Z.M.,Chuprun, J.K.,Song, J.,Gao, E.,Cheung, J.Y.,Sklar, L.A.,Koch, W.J.,Tesmer, J.J.; Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.; Acs Chem.Biol., 7:1830-1839, 2012; PubMed: 22882301; DOI: 10.1021/cb3003013

Experimental method

X-RAY DIFFRACTION (2.07 Å)