3V4Y

Crystal Structure of the first Nuclear PP1 holoenzyme

Summary for 3V4Y

• Entry DOI: 10.2210/pdb3v4y/pdb
• Related: 3EGG 3EGH 3HVQ
• Descriptor: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Nuclear inhibitor of protein phosphatase 1, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: pp1, ser/thr phosphatase, nipp1, idp, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P62136; Nucleus. Isoform Gamma: Cytoplasm: Q12972
• Total number of polymer chains: 8
• Total formula weight: 171509.85

Authors

Page, R.,Peti, W.,O'Connell, N.E.,Nichols, S. (deposition date: 2011-12-15, release date: 2012-10-31, Last modification date: 2024-02-28)

• Primary citation: O'Connell, N.,Nichols, S.R.,Heroes, E.,Beullens, M.,Bollen, M.,Peti, W.,Page, R.; The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme.; Structure, 20:1746-1756, 2012; PubMed: 22940584; DOI: 10.1016/j.str.2012.08.003

Experimental method

X-RAY DIFFRACTION (2.098 Å)