3V4J

First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G

Summary for 3V4J

• Entry DOI: 10.2210/pdb3v4j/pdb
• Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION, 4-[methyl(nitroso)amino]benzene-1,2-diol, ... (4 entities in total)
• Functional Keywords: hydrolase, apobec3g, antiviral defense, host-virus interaction, metal-binding, nucleus
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9HC16
• Total number of polymer chains: 2
• Total formula weight: 48774.05

Authors

Shandilya, S.M.D.,Ali, A.,Schiffer, C.A. (deposition date: 2011-12-15, release date: 2012-02-01, Last modification date: 2023-09-13)

• Primary citation: Li, M.,Shandilya, S.M.,Carpenter, M.A.,Rathore, A.,Brown, W.L.,Perkins, A.L.,Harki, D.A.,Solberg, J.,Hook, D.J.,Pandey, K.K.,Parniak, M.A.,Johnson, J.R.,Krogan, N.J.,Somasundaran, M.,Ali, A.,Schiffer, C.A.,Harris, R.S.; First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.; Acs Chem.Biol., 7:506-517, 2012; PubMed: 22181350; DOI: 10.1021/cb200440y

Experimental method

X-RAY DIFFRACTION (2.04 Å)