3V0W

Crystal structure of Fab WN1 222-5 in complex with LPS

Summary for 3V0W

• Entry DOI: 10.2210/pdb3v0w/pdb
• Descriptor: WN1 222-5 Fab (IgG2a) light chain, WN1 222-5 Fab (IgG2a) heavy chain, 2-amino-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-[L-glycero-alpha-D-manno-heptopyranose-(1-7)]4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-3)-4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (5 entities in total)
• Functional Keywords: beta barrel, antibody, fab, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 49644.15

Authors

Gomery, K.,Evans, S.V. (deposition date: 2011-12-08, release date: 2012-12-05, Last modification date: 2020-07-29)

• Primary citation: Gomery, K.,Muller-Loennies, S.,Brooks, C.L.,Brade, L.,Kosma, P.,Di Padova, F.,Brade, H.,Evans, S.V.; Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.; Proc.Natl.Acad.Sci.USA, 109:20877-20882, 2012; PubMed: 23184990; DOI: 10.1073/pnas.1209253109

Experimental method

X-RAY DIFFRACTION (1.73 Å)