3V0P

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor

Summary for 3V0P

• Entry DOI: 10.2210/pdb3v0p/pdb
• Related: 3IOH 3IOI 3IOJ
• Descriptor: Histo-blood group ABO system transferase, MANGANESE (II) ION, 5-(5-formylthiophen-2-yl)uridine 5'-(trihydrogen diphosphate), ... (6 entities in total)
• Functional Keywords: gta, abo, cisab mutant, rossmann fold, "closed" conformation, glycosyltransferase, glycoprotein, blood group antigen, udp-galnac, metal-binding, manganese, glycosylation, transmembrane, golgi apparatus, secreted, signal-anchor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• Total number of polymer chains: 2
• Total formula weight: 71419.57

Authors

Palcic, M.M.,Jorgensen, R. (deposition date: 2011-12-08, release date: 2013-01-23, Last modification date: 2023-09-13)

• Primary citation: Jrgensen, R.,Pesnot, T.,Lee, H.J.,Palcic, M.M.,Wagner, G.K.; Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase.; J.Biol.Chem., 288:26201-26208, 2013; PubMed: 23836908; DOI: 10.1074/jbc.M113.465963

Experimental method

X-RAY DIFFRACTION (1.9 Å)