3UXP

Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP

Summary for 3UXP

• Entry DOI: 10.2210/pdb3uxp/pdb
• Related: 3UXN 3UXO
• Descriptor: DNA polymerase beta, DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', ... (6 entities in total)
• Functional Keywords: pol beta, repair polymerase, ber, transferase, lyase-dna complex, lyase/dna
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Nucleus: P06766
• Total number of polymer chains: 6
• Total formula weight: 87623.26

Authors

Gridley, C.L.,Jaeger, J. (deposition date: 2011-12-05, release date: 2012-12-05, Last modification date: 2024-02-28)

• Primary citation: Gridley, C.L.,Rangarajan, S.,Firbank, S.,Dalal, S.,Sweasy, J.B.,Jaeger, J.; Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.; Biochemistry, 52:4422-4432, 2013; PubMed: 23651085; DOI: 10.1021/bi301368f

Experimental method

X-RAY DIFFRACTION (2.723 Å)