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3UVW

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K5acK8ac)

Summary for 3UVW
Entry DOI10.2210/pdb3uvw/pdb
Related3UV2 3UV4 3UV5 3UVD 3UVX 3UVY 3UW9
DescriptorBromodomain-containing protein 4, Histone H4, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, peptide complex, structural genomics consortium, sgc, protein binding, transcription, transcription-protein binding complex, transcription/protein binding
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus (By similarity): O60885
Nucleus: P62805
Total number of polymer chains2
Total formula weight16382.79
Authors
Primary citationFilippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149:214-231, 2012
Cited by
PubMed: 22464331
DOI: 10.1016/j.cell.2012.02.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.37 Å)
Structure validation

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