3UVV

Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid

Summary for 3UVV

Entry DOI	10.2210/pdb3uvv/pdb
Descriptor	Thyroid hormone receptor alpha, Retinoic acid receptor RXR-alpha, 3,5,3'TRIIODOTHYRONINE, ... (5 entities in total)
Functional Keywords	tr-rxr heterodimer, allostery, alpha helical sandwich, transactivation, hormone receptor-hormone receptor complex, hormone receptor/hormone receptor
Biological source	Gallus gallus (bantam,chickens) More
Cellular location	Nucleus: P04625 P19793
Total number of polymer chains	2
Total formula weight	58388.98
Authors	Fernandez, E.J.,Putcha, B.-D.K.,Wright, E.,Brunzelle, J.S. (deposition date: 2011-11-30, release date: 2012-04-18, Last modification date: 2023-11-15)
Primary citation	Putcha, B.D.,Wright, E.,Brunzelle, J.S.,Fernandez, E.J. Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers. Proc.Natl.Acad.Sci.USA, 109:6084-6087, 2012 Cited by PubMed: 22474364 DOI: 10.1073/pnas.1119852109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation