3UVP

Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone

Summary for 3UVP

Entry DOI	10.2210/pdb3uvp/pdb
Related	3QUD 3QUE 3UVQ 3UVR 3UVS
Descriptor	Mitogen-activated protein kinase 14, N-{2-fluoro-5-[(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino]phenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	protein kinase, selective p38 inhibitor, sar, benzosuberon derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42242.23
Authors	Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (deposition date: 2011-11-30, release date: 2012-11-07, Last modification date: 2023-11-08)
Primary citation	Martz, K.E.,Dorn, A.,Baur, B.,Schattel, V.,Goettert, M.I.,Mayer-Wrangowski, S.C.,Rauh, D.,Laufer, S.A. Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha Inhibitors. J.Med.Chem., 55:7862-7874, 2012 Cited by PubMed: 22897496 DOI: 10.1021/jm300951u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation