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3UO9

Crystal Structure of Human GAC in Complex with Glutamate and BPTES

Summary for 3UO9
Entry DOI10.2210/pdb3uo9/pdb
Related3UNW
DescriptorGlutaminase kidney isoform, mitochondrial, GLYCEROL, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide), ... (4 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925
Total number of polymer chains4
Total formula weight237169.71
Authors
DeLaBarre, B.,Gross, S.,Cheng, F.,Gao, Y.,Jha, A.,Jiang, F.,Song, J.J.,Wei, W.,Hurov, J.B. (deposition date: 2011-11-16, release date: 2011-12-07, Last modification date: 2024-02-28)
Primary citationDeLaBarre, B.,Gross, S.,Fang, C.,Gao, Y.,Jha, A.,Jiang, F.,Song J, J.,Wei, W.,Hurov, J.B.
Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50:10764-10770, 2011
Cited by
PubMed: 22049910
DOI: 10.1021/bi201613d
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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