3ULI

Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative

Summary for 3ULI

Entry DOI	10.2210/pdb3uli/pdb
Descriptor	Cyclin-dependent kinase 2, 1-(aminomethyl)-N-(3-{[6-bromo-2-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]amino}propyl)cyclopropanecarboxamide (3 entities in total)
Functional Keywords	azabenzimidazole derivative, phosphotransfer, complex with cyclin a or cyclin e, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34449.85
Authors	Larsen, N.A.,Tucker, J.A.,Wang, T. (deposition date: 2011-11-10, release date: 2013-08-14, Last modification date: 2024-02-28)
Primary citation	Wang, T.,Block, M.A.,Cowen, S.,Davies, A.M.,Devereaux, E.,Gingipalli, L.,Johannes, J.,Larsen, N.A.,Su, Q.,Tucker, J.A.,Whitston, D.,Wu, J.,Zhang, H.J.,Zinda, M.,Chuaqui, C. Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKK epsilon kinases. Bioorg.Med.Chem.Lett., 22:2063-2069, 2012 Cited by PubMed: 22305584 DOI: 10.1016/j.bmcl.2012.01.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation