3UG1

Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form

Summary for 3UG1

Entry DOI	10.2210/pdb3ug1/pdb
Related	2EB2 2EB3 3UG2 3VJN 3VJO
Descriptor	Epidermal growth factor receptor, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	kinase, tyrosine-protein kinase, transferase, atp binding, phosphorylation, transmembrane, receptor, disease mutation, cell cycle, drug resistance
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38233.28
Authors	Parker, L.J.,Handa, N.,Yoshikawa, S.,Kukimoto-Niino, M.,Shirouzu, M.,Yokoyama, S. (deposition date: 2011-11-02, release date: 2012-03-07, Last modification date: 2023-11-01)
Primary citation	Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Oncogene, 32:27-38, 2013 Cited by PubMed: 22349823 DOI: 10.1038/onc.2012.21 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation