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3UFS

Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-((5-(3-chloro-5-fluorophenyl)pentyl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

Summary for 3UFS
Entry DOI10.2210/pdb3ufs/pdb
Related3UFO 3UFP 3UFQ 3UFR 3UFT 3UFU 3UFV 3UFW
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100335.89
Authors
Li, H.,Poulos, T.L. (deposition date: 2011-11-01, release date: 2012-07-11, Last modification date: 2023-09-13)
Primary citationHuang, H.,Ji, H.,Li, H.,Jing, Q.,Labby, K.J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J.Am.Chem.Soc., 134:11559-11572, 2012
Cited by
PubMed: 22731813
DOI: 10.1021/ja302269r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.971 Å)
Structure validation

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