3UE4

Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain

Summary for 3UE4

Entry DOI	10.2210/pdb3ue4/pdb
Descriptor	Tyrosine-protein kinase ABL1, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (3 entities in total)
Functional Keywords	protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	2
Total formula weight	67506.87
Authors	Boxer, S.G.,Levinson, N.M. (deposition date: 2011-10-28, release date: 2012-04-18, Last modification date: 2024-02-28)
Primary citation	Levinson, N.M.,Boxer, S.G. Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the abl tyrosine kinase domain. Plos One, 7:e29828-e29828, 2012 Cited by PubMed: 22493660 DOI: 10.1371/journal.pone.0029828 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.424 Å)

Structure validation